Study shows urolithin A improves muscle strength in middle-aged adults

New research by scientists in Switzerland shows that urolithin A supplementation had similar effects to exercise on muscle strength, improving it by 12% after 4 months.

Amazentis, a Swiss Federal Institute (EPFL) spin-off company pioneering scientific advances in cellular health and nutrition, today announced that the peer-reviewed clinical and translational journal Cell Reports Medicine has published new clinical results showing the muscle health benefits of postbiotic urolithin A from the gut microbiome.

Longevity. Technology: Age-associated muscle decline can begin as early as age 40, and there are currently no effective interventions to counteract it other than exercise.

This landmark study showed that daily intake of Amazentis’ proprietary urolithin A, Mitopure, significantly improved muscle strength by 12% after four months. [1]. According to the company, these findings further validate the benefits of Mitopure for muscle and mitochondrial health and demonstrate that it is safe and well tolerated.

Mitopure works by supporting the cells’ ability to renew their powerhouses, the mitochondria, during the aging process. Since muscles have a high demand for energy, there are a large number of mitochondria in muscle cells.

Previous research has shown that Mitopure improved muscular endurance, reduced inflammation and resulted in healthier mitochondrial function in older adults ages 65 to 90 [2]. This new double-blind, placebo-controlled trial in middle-aged adults aged 40 to 64 years (n=88) was conducted in London, Ontario, Canada, following approvals from Health Canada and an independent IRB. Participants were randomized to receive daily supplementation with 500 mg, 1000 mg of Mitopure, or placebo for 4 months.

What did the results show?

Muscle strength, exercise performance tests, and biomarkers of healthy mitochondrial function and inflammation in skeletal muscle biopsies and blood plasma were assessed at baseline, 2 months, and 4 months.

  • Two measures of skeletal muscle strength were improved in the supplemented groups compared to the placebo group. Muscle strength in hamstring skeletal muscle was significantly increased in the 500 mg (+12%) and 1000 mg (+9.8%) groups. Muscle strength during knee flexion was also significantly improved at the 500 mg (+10.6%) and 1000 mg (+10.5%) doses.
  • Clinically significant improvements in aerobic endurance (+10% in maximal oxygen uptake) [VO2]), physical performance (+33 meters in the 6-minute walk test) and power output (+5%) were observed in the 1000 mg group, although not statistically significant
  • Blood tests and biopsies showed significant improvement in biomarkers of healthy mitochondrial function and reduced inflammation

“These results are exciting because it is the first human demonstration that urolithin A repairs mitochondria through mitophagy and can translate into significant physiological benefits. Furthermore, the improvement in strength and exercise performance occurred in the absence of changes in the participants’ exercise routine,” explained Johan Auwerx, MD, PhD, co-author and professor at the Swiss Federal Institute of Technology EPFL.

READ MORE: Taking Mitopure Urolithin A Supplements for Faster Muscle Recovery.

An important scientific discovery.

This is an important discovery in research on longevity and muscle health. Aging is associated with a decline in mitochondrial function, which can lead to reduced exercise capacity, muscular endurance, and strength. Mitochondrial dysfunction is one of the hallmarks of aging, and the mitophagy process serves as a mitochondrial quality control mechanism, allowing for the cleansing of damaged and dysfunctional mitochondria and helping to restore cellular homeostasis.

Mitophagy typically occurs due to potentially damaging conditions, such as oxidative stress, hypoxia, loss of mitochondrial transmembrane potential, accumulation of unfolded proteins, and iron loss. [3]But being able to trigger mitophagy, without a pre-existing damaging state, could increase the amount of energy available to the body for repair and growth.

Urolithin A can activate mitophagy [4 ] and has now been clinically shown to improve muscle function through this process [1]. By activating this important biological pathway, Mitopure seeks to promote healthy aging and improved muscle health and performance.

Aging is associated with a decline in mitochondrial function, which can lead to reduced exercise capacity, muscular endurance, and strength.
Chris Rinsch, CEO and co-founder of Amazentis

“This study further validates the role of mitochondrial health as an important pillar of vitality and shows that Mitopure is a world-class nutrient that has a significant impact on muscle health. We are proud to offer this patented form of urolithin A in our Timeline® brand and within Nestlé Health Science products,” said Chris Rinsch, CEO and co-founder of Amazentis. “We remain committed to pioneering clinically validated products that optimize cellular health with a mission to keep millions of people healthy longer.”

Dr. Eric Verdin

Additionally, Amazentis also announced that Dr. Eric Verdin has joined the Amazentis Scientific Advisory Board. Dr. Verdin is the President and CEO of the Buck Institute for Research on Aging and has dedicated his career to the study of longevity with the goal of transforming everyone into healthy centenarians.

“Mitochondrial decline is a key hallmark of aging and poor metabolic health. This study is an important milestone and shows that urolithin A could be a game changer in our field.” Verdin said.

READ MORE: Protect Mitochondria and Muscle Health with Mitopure.

[1] https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00158-6
[2] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788244
[3] https://www.frontiersin.org/articles/10.3389/fcell.2020.00200/full
[4] https://www.nature.com/articles/s41598-022-11894-2

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